RyMat Inc
Stuart Silverman
CEO & Founder
(803) 397-8087

RyMat Inc.

Solution Provider to the Pharmaceutical Industry

Publications

"Practical Asymmetric Synthesis of Efavirenz (DMP 266), an HIV-1 Reverse Transcriptase Inhibitor." The Journal of Organic Chemistry 1998
2 authors: Stuart Silverman CEO & Founder, RyMat Inc.; Michael E. Pierce Rodney L. Parsons Jr. Lilian A. Radesca Young S. Lo Stuart Silverman James R. Moore. Chemical Process R&D Department, Process Research Facility, The DuPont Pharmaceuticals Company, Deepwater, New Jersey 08023-0999

“An efficient synthesis of DNA repair inhibitor DMP 315. Convenient synthesis of unsymmetrical(bis)napthylimides.”
2 authors: Stuart SilvermanCEO & Founder, RyMat Inc.Joseph M.D. Fortunak Michael E. Pierce Stuart Silverman Susan J. Morgan and R.L. Dorow. Chemical Process R&D Department, Process Research Facility, The DuPont Pharmaceuticals Company, Deepwater, New Jersey 08023-0999

"N-aryl-3,3,3-trifluoro-2-hydroxy-2-methylpropanamides: KATP potassium channel openers. Modifications on the western region." Ohnmacht CJ1, Russell K, Empfield JR, Frank CA, Gibson KH, Mayhugh DR, McLaren FM, Shapiro HS, Brown FJ, Trainor DA, Ceccarelli C, Lin MM, Masek BB, Forst JM, Harris RJ, Hulsizer JM, Lewis JJ, Silverman SM, Smith RW, Warwick PJ, Kau ST, Chun AL, Grant TL, Howe BB, Neilson KL, et al. J. Med. Chem., 1996, 39 (23), pp 4592–4601 Departments of Medicinal Chemistry, Pharmacology, and Drug Disposition and Metabolism, Zeneca Pharmaceuticals, A Division of Zeneca Inc., Wilmington, Delaware 19897, and Zeneca Pharmaceuticals, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, U.K.


"Tertiary Carbinols: Carbon Backbone Linkers As Replacements For The Amide Moiety." 

James R. Empfield, Thomas Grant, Tracy J. Halterman, Burton B. Howe, Sen T. Kau, Jack H. Li, Daniel R. Mayhugh, Keith Russell, Stuart M. Silverman, Sephali Trivedi, and Christopher Yochim.  Departments of Medicinal Chemistry, Pharmacology, and Drug Disposition and Metabolism, Zeneca Pharmaceuticals, A Division of Zeneca Inc., Wilmington, Delaware 19897, and Zeneca Pharmaceuticals, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, U.K., Presented at the 207th National Meeting of the American Chemical Society, San Diego California, March 13 1994


Tertiary Carbinols: A Novel Series of K-ATP Sensitive Potassium Channel Openers For use In Urinary Incontinence
Presented at the 207th National Meeting of the American Chemical Society, San Diego California, March 13 1994
2 authors: Stuart Silverman, CEO & Founder, RyMat Inc.James E. Empfield. Departments of Medicinal Chemistry, Pharmacology, and Drug Disposition and Metabolism, Zeneca Pharmaceuticals, A Division of Zeneca Inc., Wilmington, Delaware 19897, and Zeneca Pharmaceuticals, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, U.K.

"A Method For Determination of the Oxime Stereochemistry of Isatin-3-Oximes Utilizing 13-C NMR Spectroscopy" Stuart M. Silverman, William J. Frazee, Zeneca Pharmaceuticals Group, A Business Unit of ICI Inc. Wilmington, DE 19897

Presented at the 203rd National Meeting of the American Chemical Society, San Francisco, California  April 5, 1992